Your body whom does not understand the mind of a bodybuilder thinks, "I starving, there is a drought, calories are insufficient, I am losing body fat…slow down all metabolic systems until body fat return to normal." Your own body tries to sabotage your competition goals of losing fat by slowing down your metabolism and breaking down lean muscle mass as an energy source. During a calorie-restricted diet the sympathetic nervous system is decreased, this decrease in sympathetic nerve activity results in a reduction in lower metabolic rate thus conserving reserves of nutrients, although this is not necessarily true for adipose tissue. During fasting or calorie restriction, adipose tissue readily releases stored energy. That is where thermogenic supplements come in handy because they increase sympathetic nervous system activity and restores sympathetic tone. One of the ways caffeine and ephedrine stimulates lipolysis is by increasing the release of the "fight-or flight" hormones called catecholamines. The major Forskohlii are dopamine, norepinephrine, and epinephrine (also known as adrenaline). Maintaining or increasing lean body mass should be one of the most important strategies for any weight reduction program. By maintaining lean muscle, mass during dieting maintains the body's thermogenic response to food and basal metabolic rate.
Stimulating fat metabolism is the result of mobilizing fat stores in which stored fat is mobilized by the hydrolysis of free fatty acids and glycerol. This is initiated by the rise in a variety of hormones such as norepinephrine, epinephrine, ACTH, and glucagon. The mechanisms of these lipolytic hormones are believed to be mediated by an increase in cAMP. Lipolytic hormones activate adenylate cyclase, resulting in increased synthesis of cAMP-dependent protein kinases and subsequent phosphyorylation and activation of hormone-sensitive lipase, resulting in the hydrolysis of stored triglycerides to glycerol and free fatty acids. Hormone sensitive lipase is the rate-limiting enzyme in triglyceride breakdown and lipolysis. Adenylate Cyclase is an enzyme that activates cAMP or Cyclic Adenosine Monophosphate in the cell. cAMP promotes breakdown of stored fats, regulates thermogenic responses to food, increases the body's basal metabolic rate, and increases the utilization of body-fat.